What better place to start than at the very beginning with first ever appearance of Black Panther?
The four are then attacked by the Black Panther, who beats up all of them at the same time.
In the issues, the Fantastic Four are invited to the African nation of Wakanda, where they meet T’Challa, an enigmatic leader of a tribe.
While there are some who likely thought that Black Panther made his debut with the Avengers — the team he is most associated with — the character actually first appeared in the pages of Fantastic Four, or the Mother Book, as I like to call it.