That said, S.H.I.E.L.D. has been pretty straightforward in setting up his death in Season 5.
On the one hand, Coulson is the closest that Agents of S.H.I.E.L.D. has to a lead character, and he’s the show’s biggest connection to the larger Marvel Cinematic Universe.
We can bet that he’ll be 100% against using the remaining Centipede Serum to save his own life, especially when the entire world is at stake.
Talbot must be stopped before he uses his powers to split the planet apart to get at the gravitonium reserves, and Coulson would certainly give his life to prevent such a thing from happening.