The Russos’ specific mention that Red Skull could pursue an Infinity Stone seem to strongly hint that he will, likely to fulfill his long-held dream of world domination.
Who knows though, he might shock everyone and chill on a remote island until this all blows over.
Of course, we’re talking about an exiled super-Nazi who’s been enslaved by sentient Stones for several decades, so it’s not like his options are completely open to doing a ton outside the world of villainy.