The idea that anyone can be Spider-Man is the driving force of Into the Spider-Verse and Superior Spider-Man fits that theme almost too perfectly.
However, the change was pretty popular and Marvel found a way to get Ock back as Superior Spider-Man.
While not technically a villain, Superior Spider-Man certainly started out that way.
In one final gambit for victory, a dying Doctor Octopus swapped bodies with Peter Parker and successfully took over his life.
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