The project was created way back in 1990, and the experimentation led to John Garrett becoming the first ever Deathlok soldier.
His reappearance reminded the agents (and the audience) about Project Deathlok, which turned Mike into a cyborg against his will.
His significance in Season 5 has everything to do with how he was able to live as long as he did.
He also ultimately became a supervillain who did a lot of damage to innocent lives and S.H.I.E.L.D., and he was the big bad of Season 1.
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