The show won best comedy series ensemble, best actress in a comedy series for Rachel Brosnahan, and best actor in a comedy series for Tony Shalhoub, whose win was a surprise in a category that included Bill Hader (Barry) and Michael Douglas (The Kominsky Method).
The Marvelous Mrs Maisel kicked off the 25th annual Screen Actors Guild by winning the first three trophies of the night.
Barry, GLOW, The Handmaid’s Tale and The Kominsky Method trailed close behind with three nominations each.
Set in the late 1950s, the comedy-drama was created by Amy Sherman-Palladino, also known for her cult classic creation Gilmore Girls.