At one point it was being reported that Elizabeth Moss was going to take the main role, and while it was later confirmed that she is in the movie, she’s playing somebody else.
It’s a pretty significant step up considering that previously Johnny Depp was on board to play the title role, back when The Invisible Man was set to be a part of the Dark Universe, a cinematic universe concept that would have been made up of all of Universal Pictures classic movie monsters.