This is a direct reference to the events that took place in Civil War where the Avengers, including Wanda, tried to stop HYDRA agent Brock Rumlow from stealing a bioweapon.
The fourth commercial in the recently released fifth episode “On A Very Special Episode” is a nod to the moment when Wanda was left questioning and blaming herself in Civil War.
The first commercial was a Captain America: Civil War reference to the harrowing moment in Wanda and Pietro’s childhood when a missile by the Stark Industries killed their parents and destroyed their home.
And the third commercial, while not explicit like the first two, hinted at the time she briefly worked for HYDRA.