The Big Bang Theory star was up for two awards for her performance in HBO series The Flight Attendant, including Best Actress in a Musical or Comedy.
Emma Corrin took home Best Actress for her performance as Princess Diana.
It’s unlikely that Cuoco felt too sore about the loss, however, as just two days before the Golden Globes took place she shared a photo of herself meeting O’Hara for the first time.
“Anyone who knows me knows what this moment meant to me,” she wrote in the caption.