“We believe that being part of the EU bolsters Britain’s leading role on the world stage.”
“From the Bard to Bowie, British creativity inspires and influences the rest of the world,” it says.
The bands Hot Chip and Editors have signed the letter, as has Pulp frontman Jarvis Cocker.
The appeal was coordinated by Britain Stronger in Europe, the official campaign to persuade voters to remain in the EU, in which Downing Street is closely involved.