Other actors have expressed interest in returning, and Netflix is clearly interested in making it happen, but it all comes down to the details.
Alexis Bledel’s answer quite sensible, as she would dictate her return based on if the story was good enough to warrant such a thing.
Such as Lauren Graham being a part of a new project, as well as Sherman-Palladino’s new Amazon comedy, since both of those things could create a scheduling nightmare.
and one assumes that creator Amy Sherman-Palladino has other interesting directions to take this story that would please both actresses and more.