The way I see it, with Tom Holland having contributed to the MCU and Pixar, that just leaves two main areas of Disney for Tom Holland to show up in: a Star Wars movie and one of the studio’s live action remakes/re-imaginings.
And Disney certainly isn’t slowing down on putting live-action spins on its classic animated movies, so there could be room for Holland in one of those.
Something tells me that if Holland were to ever show up in the Star Wars franchise, it would be through a cameo rather than as one of the leading characters, but anything’s possible.