Given the title and synopsis, whatever events unfold that lead to their saving appear to be tied to Ghost Rider.
Agents of S.H.I.E.L.D. returns November 29th with ‘Deals With Our Devils’ on ABC.
The surprise of the clip itself is Mack, who has repeatedly disagreed with working with Ghost Rider, potentially setting out to find him.
While it is still unclear how Ghost Rider, Coulson, and Fitz will be saved, their appearances in the episode have already been shown in promotional stills.