The series is created by newcomers Zach Wechter and Jack Seidman, who will also serve as executive producers with Wechter also set to direct.
MacDowell most recently starred in the comedy horror film Ready or Not which had its premiere last August.
The series will be set inside the car he crashed and the quickly dying phone that now is his lifeline.
Deadline brings word that Golden Globe nominee Andie MacDowell (Four Weddings and a Funeral) has signed on for a key role in Quibi’s forthcoming survival thriller series Wireless which will be executive produced by Steven Soderbergh.