It has already been revealed that Supergirl will be the focus of the multi-show crossovers, but how that will be done is still a mystery.
That means the Legion of Doom could follow them to Supergirl’s universe, or one of Supergirl’s enemies could join the Legion of Doom.
Where there’s a will, however, there’s a way, and having multiple universes collide is a hallmark of DC comics.
Captain Cold (Wentworth Miller)–certainly pose a formidable threat, and represent a cross-section of villains from all of The CW’s DC shows as of last season.