The Sherlock star will appear as Satan in Good Omens, Amazon and the BBC’s adaptation of Neil Gaiman and Terry Pratchett’s fantasy novel, which is due to air in May.
A collaboration between Gaiman and Pratchett, who died in 2015, Good Omens was first released in 1990.
Good Omens debuts on 31 May on Amazon Prime, with all six episodes appearing in one go.
Benedict Cumberbatch is set to follow up his role as Brexit architect Dominic Cummings by playing another famously contentious figure.