I’m not sure anyone’s actively targeting Mark right now, but once he’s on the block, that question will undoubtedly be raised.
Mark raised a good point in discussing that lesser-liked houseguests do seem to be getting unintentional protection because they’re on the outside.
Ramses isn’t high on anyone’s list of friends or allies, and yet he’s not on the block, for example.
Jessica is most likely being pulled off the block with the Veto, and what’s to say the house won’t decide to keep Dominique around if they have the chance to take Mark out.