(In the original Crisis on Infinite Earths comic, Superman met his counterparts from many different Earths, so it’s definitely possible.)
Routh himself got very positive reviews in his gig replacing Reeve, but the film itself was met with a more lukewarm reaction.
Routh already plays an Arrowverse character; he’s Ray Palmer, AKA the size-changing hero known as the Atom, on Legends of Tomorrow.
Instead of going ahead with a planned sequel, Warner Bros. handed the Superman series to Batman auteur Christopher Nolan, who produced Man of Steel in 2013.