It has also forced workers at the Shambala Preserve, an animal sanctuary founded by Tippi Hedren, to evacuate most of its animals, according to the Hollywood Reporter.
The Los Angeles County sheriff’s department is investigating the death of a man who was thought to be caught in the blaze.
It’s home to several species of endangered big cats, including African lions, leopards and a Bengal tiger.
Derek Hunt, owner of the Sable Ranch film set, said the fire came down the hillside towards the site “like a freight train”.