American Dad’s Scott Grimes will reteam with MacFarlane as Ed’s best friend Gordon, who is brought in to pilot the Orville.
Set 300 years in the future, Orville takes place on the titular spaceship that isn’t exactly the most high-quality craft soaring through the cosmos.
Shameless’ Peter Macon and The Cleveland Show’s J Lee will play other members of the ship’s crew.
MacFarlane stars as the ship’s captain, Ed, while Agents of S.H.I.E.L.D.’s Adrienne Palicki will be Ed’s first officer Kelly, who also happens to be his ex-wife.