Lincoln and Sara were both deeply affected by Michael’s apparent death, while Michael actually didn’t die and ended up in yet another prison.
Wentworth Miller revealed the possibility for a Prison Break Season 6 in a chat with EW, and it paints an interesting picture of the potential future for the characters.
Miller’s tease of a possible Season 6 indicates that all the loose ends will not be totally wrapped up by the end of Season 5.
The action of Season 5 picked up seven years after the end of Season 4, and it revealed that the main characters went in very different directions.