The most recent entry, Scream 4, released in 2011 and grossed $97 million worldwide on a $40 million budget.
“I am thrilled to be playing Dewey again and to reunite with my Scream family, old and new.
Neve Campbell (Party of Five, The Craft) has played Sidney Prescott in the original blockbuster hit Scream way back in 1996.
Scream been such a big part of my life, and for both the fans and myself, I look forward to honoring Wes Craven’s legacy,” Arquette said in a statement.