If this PG-13 version of Deadpool 2 is a proper indication, the answer is no.
Reports claim Deadpool will stay R-rated, but will that interfere with his MCU prospects?
Granted, it might not be fair to judge Once Upon A Deadpool on its own since it’s a deliberate, even cheeky attempt to make Deadpool 2 family-friendly.
While there were folks who might’ve enjoyed the retooled sequel more, the general conscious was mixed-at-best.