Later, Chameleon took a serum that actually gave him disguising powers, though he still relies on costuming and his innate acting abilities to effectively pass himself off as another person.
Debuting in 1963’s The Amazing Spider-Man #1, The Chameleon was the first super villain Spider-Man fought.
Outside of the comics, Chameleon’s other media appearances include Spider-Man: The Animated Series and The Spectacular Spider-Man.
Chameleon is also Kraven the Hunter’s cousin, and is responsible for putting the big game hunter on Spider-Man’s tail.