Drew Barrymore famously played the ill-fated Casey Becker in the iconic opening sequence, but she was originally offered the role of Sidney (Neve Campbell).
The genre bending horror movies made a ton of money, and Scream 5 is currently in development.
The horror genre was built on long-running franchises like Halloween and Friday the 13th.
And Barrymore recently explained why she went this surprising career choice, in favor of being killed off.