But would an inoffensive Family Guy really be Family Guy any more?
Since 1999, Family Guy has followed the adventures of Quahog, Rhode Island, dad Peter Griffin, wife Lois, and children Meg, Chris and villainous baby Stewie, and their laconic dog Brian.
Family Guy has done this even as MacFarlane has polished his credentials as an archetypal left-leaning Tinsel Town good guy.
Family Guy splashed down on a Sunday night, straight after John Elway led the Denver Broncos to the 1999 Super Bowl.