With appearances in over 100 episodes as the non sequitur-espousing mayor of Quahog and his recorded episode count dwindling, the Family Guy team will have to make a decision sooner or later on whether to continue the character in some different form, or perhaps write his character off and introduce another city leader to the fold.
The death of Adam West will likely hit the show harder than other celebrity deaths, considering Mayor West was a longtime member of the series.
It’s possible Family Guy will introduce that solution midway through Season 16, which debuts in October, or they could push things further to Season 17 and deal with it then.