The most obvious guess would be that something will happen to Jenna Elfman’s June, though I don’t think they’d tease that potential whopper right there in the trailer.
Perhaps something ends up happening to Maggie Grace’s Althea, considering she’s barely in the Season 6 trailer.
Arguably the most ominous moment in the trailer is Garret Dillahunt’s trip to the makeshift cemetery, and with the words “Is Dead” on display, no less.
We don’t know who his character John Dorie would be mourning in such a way, but that feeling is likely also there during John’s other shot in the trailer.