Clooney earned some $200m more than the highest-paid female actor, Scarlett Johansson, whose $40.5m total is thought to largely derive from her involvement in Marvel titles.
In 2013, Clooney co-founded Casamigos with Rande Gerber and Mike Meldman, initially as a way to supply them personally with sufficient quantities of high-quality liquor.
Johnson doubled his earnings year on year, making $119m (£92m) from his involvement in multiple blockbusters, including Skyscraper and Rampage.
She earned four times as much as Gal Gadot, who plays Wonder Woman in films by rival comic book outfit DC.