If negotiations follow through, Harrison will play John Thornton, a prospector braving the Yukon on the hunt for gold.
The novel focuses on the Klondike gold rush of the 1890s from the point of view of a sled dog named Buck.
Diana Pokorny (Downsizing, Daddy’s Home) will serve as executive producer with Steve Asbell overseeing the feature for Fox.
The big-budget live-action film is being directed by Oscar nominee Chris Sanders (The Croods, How to Train Your Dragon) from a screenplay by Oscar nominee Michael Green (Logan, American Gods).