The judge in the case, James Burke, will closely instruct the jury how to work through the five charges facing Weinstein, 67.
If the jury finds Weinstein guilty of the charges relating to either or both of the main accusers it can then move on to consider the final two counts: predatory sexual assault.
The jury of 12 New Yorkers will begin a potentially testing deliberation on whether or not to find the disgraced movie mogul guilty of rape and sexual assault.
Seven men and five women will be sent out of courtroom 99 at the New York supreme court on Tuesday carrying the fate of Harvey Weinstein and the #MeToo movement on their shoulders.