Debuting in 1963’s The Amazing Spider-Man #2, Vulture was the second super villain who Spider-Man faced in the comics, preceded by The Chameleon.
In that continuity, Vulture’s wings were seen at the end of The Amazing Spider-Man 2, and had that series continued, it looked like he would have been a member of the Sinister Six.
So now we know for sure that Vulture will be Spider-Man: Homecoming’s main antagonist, but he may not be the movie’s only villain.
Unfortunately, his face is obscured by shadows, and the actor playing Vulture wasn’t mentioned at the movie’s Hall H presentation.