In His Dark Materials Season 2 Episode 2, Will took Lyra to his Oxford, and as the acting Cardinal, MacPhail made moves against the witches.
In the previous episode of HBO’s His Dark Materials, Will and Lyra met in another world, and Father MacPhail and Mrs. Coulter conspired to kill Cardinal Sturrock.
The alethiometer led Lyra to Dr. Malone, a physicist studying dark matter.
Lyra explained to Dr. Malone that in her world, the Magisterium hated Dust because it’s original sin.