This was most definitely the way that Octavia Spencer felt going in to playing God (or at least an aspect of God) in the new movie The Shack, and it was a process that demanded a close relationship with director Stuart Hazeldine, as well as strong focus on what she wanted her performance to be.
As any actor will tell you, there are some roles that are held in a bit higher esteem than others.
This certainly also extends to religious figures as well, as there is a specific responsibility that comes with playing a person or entity that is worshiped.
Most Shakespearean leads are on this list, as are Batman and James Bond.