Every season has been rough on Sam and Dean, so, of course, Season 15 will be no different.
This is going to include them losing people “in a very real way,” and having some of their old reliable tricks / talents not work, meaning that getting to the finale is going to be even more difficult than usual.
For Supernatural and it’s never ending apocalypses, that’s really saying something.
With God opening all the doors in Hell in the Season 14 finale (which you can catch up on via Blu-ray or DVD) and unleashing everything the brothers have ever vanquished, they’re going to be fighting some old foes, along with the new threats.