The Lost Village will actively acknowledge the well-worn idea that Smurfette (Demi Lovato) is a creation of Gargamel who feels isolated because she’s the only female Smurf.
So it more or less sounds like Smurfs: The Lost Village exists in a gray area of continuity.
In that regard, it’s a genuine standalone that could fit almost anywhere in the Smurfs lore.
The new film isn’t going to acknowledge the events of the recent live-action movies, and it’s going to return to the original animated format of the series.