In one of the most emotional scenes in Infinity War, Red Skull informs Thanos that he will have to sacrifice something that he loves in order to obtain the Soul Stone.
Fast forward to Infinity War when Gamora leads Thanos to Vormir to obtain the Soul Stone.
The Tesseract contains the Space Stone and Red Skull uses it as a force against the Nazis and the Axis.
First things first, there are major SPOILERS for Avengers: Infinity War in this article, so read at your own risk.