Hell, one could argue that a spot for an anti-depressant, putting aside its name, is the most on-the-nose yet.
And there are also the pair of HYDRA related spots (Strucker Watches and HYDRA Soak) that recall the painful experiments that gave Scarlet Witch and Quicksilver their abilities.
The Stark Industries Toaster, for example, with its eerie slow-blinking red light, is reminiscent of the story that Wanda tells in Avengers: Age of Ultron about the Stark Industries missile that landed in the Maximoff house when she was a child and kept her and Pietro frozen while waiting for an explosion.
The reason I’m so confident that the WandaVision commercial is tied to the 2015 film is because it fits with a larger pattern that has emerged from the collection: they all seem to be about trauma.