Internationally, the film earned $81.6 million on 20,400 screens in 65 markets, for a worldwide total of $142.6 million its first weekend.
$12.4 million of the global total came from 674 IMAX screens in 63 markets, which marks the second-highest grossing global March opening ever in IMAX without China.
Made for just $4.5 million, the Jordan Peele film stars Daniel Kaluuya, Allison Williams, Bradley Whitford, Caleb Landry Jones and Catherine Keener.
Impressing in limited release was the Kristen Stewart-starrer Personal Shopper, which earned $92,516 from just four theaters, an average of $23,129 per theater.