As noted, Kraven the Hunter will not be a part of the established MCU, which features Tom Holland as Spider-Man.
An appearance from Spider-Man can only help the film, recognizing Kraven as a formidable foe to a popular Marvel superhero.
The screenplay for the film is currently being fleshed out by writer Richard Wenk (The Equalizer 2), who has big plans for the story.
Although Kraven the Hunter will focus mainly on the titular Spidey foe, Richard Wenk has revealed in an interview about the film that Spider-Man himself is going to appear, teasing a battle between the two characters.