The comic versions of the Runaways kids and Cloak and Dagger had some fascinating arcs in Marvel Comics, and the ages of Cloak and Dagger on the Freeform series would mean that they could fit right in with the Runaways.
Now, given the scope of Marvel Television nowadays, the next question has to be whether Cloak and Dagger will cross over with some of the other series.
Teens with bizarre powers and parental issues can totally bond, right?
The new show hasn’t firmly placed itself in the MCU at this point, so it could technically be more of a Legion than an Agents of S.H.I.E.L.D., but it would be a great fit for a crossover with at least Runaways.