They got into a fight that ended with May beating Enoch into submission with a fire extinguisher, after which she shrugged off LMD Coulson and submitted to Simmons sedating her again.
Although Simmons’ timely intervention at the end of Season 6 brought May back after being only briefly dead, she doesn’t seem to be the same May who battled Izel.
May seemed to show some Chronicom-esque characteristics after waking up.