While Fillion might have been the perfect choice to play Drake back when the games were new, it’s been a decade since then, and Fillion is probably too old to play Nathan Drake in his prime, the version we see in the games, but he could absolutely play an older Nathan Drake, maybe somebody nearing the end of his career, looking back on how it all started.
Of course, the best possible role, and potentially the one the Instagram post is actually hinting at, is that Nathan Fillion could play Nathan Drake after all.
What if the plan is for the first Uncharted movie to be told as a flashback, and it opens on Nathan Fillion as Drake looking back on his younger days?