The Happytime Murders’ human players include Elizabeth Banks as Jenny, a burlesque dancer who used to be on The Happytime Gang; Joel McHale as Agent Campbell, an FBI agent; Maya Rudolph’s Bubbles, Phil’s secretary; and Leslie David Baker as Lieutenant Banning, Connie’s superior, while the puppeteers include Bill Barretta as Phil; Julianne Buescher as Piddles, who Phil has a no-strings relationship with (pun fully intended), Dorien Davies as Sandra, who asks Phil to solve a case for her and Drew Massey as both Goofer, a former Happytime Gang cast member who’s now a prostitute.
Set in a world where puppets live alongside humans, albeit with the former considered inferior to the latter, The Happytime Murders follows Melissa McCarthy’s Detective Connie Edwards re-teaming with her ex-partner Phil Phillips to track down the serial killer that murdered Phil’s brother and is now targeting the cast of the 1980s TV show The Happytime Gang.