(For one thing, producer Barbara Broccoli has said that she thinks James Bond should be played by a man.)
And in their final battle, Safin infects Bond with a virus specifically programmed to kill 007’s one true love, Madeleine Swann.
The following post contains major SPOILERS for No Time to Die.
To understand No Time to Die’s ending, you have to understand Daniel Craig’s tenure as James Bond in the context of the 40+ years of Bond movies that preceded him.