There is a bit of a roadblock in terms of making Ross Marquand’s particular vision for Red Skull’s return a reality.
Chris Evans has been pretty clear that he’s hung up his shield and won’t be reprising his role as Steve Rogers, and it’s hard to imagine anyone else taking on the role for a standalone film.
Of course, he could change his mind and, even if he didn’t, there would still be room for Red Skull to make his return in a future installment, either in a theatrical release or even on a Disney+ series.