If we’re going by the cartoon, then you have to include Krang, Bebop, and Rocksteady, who weren’t in the comic and were made specifically for the cartoon (likely to sell more toys).
If that’s the case, then Krang is the angry housewife, and Bebop and Rocksteady are their knucklehead children.
They were just as entertaining as the Turtles, as I loved seeing their antics in the Technodrome.
Add in all the other bizarre characters like Baxter Stockman and Leatherhead, and you had a cast of villains worthy of Batman’s rogues gallery.