While the Adult Swim series essentially capitalizes on the perspective of the most intelligent being in infinite realities, Solar Opposites appears to be going for a more fish-out-of-water take on modern life and all its insanity – including the consumption of sodas that make us dumber (specifically when applied directly to the brain) and the significance of buttholes when spending life in prison.
Given the previous work of the co-creators, the show definitely seems to share comedic sensibilities with Rick & Morty, but it also looks like the approach is different enough that it will still feel fresh.