As the head of Prodigium, there’s a strong possibility that Dr. Henry Jekyll will be back for future movies.
We already know that Prodigium will be the connective thread between each of the movies, much like Claire Temple is the connective thread between Marvel’s Netflix shows.
The good news for those involved with Universal’s Dark Universe is that Russell Crowe should theoretically be around for more shenanigans in future movies, which will include characters like the Creature from the Black Lagoon, The Invisible Man, Frankenstein’s Monster and more.