If the virus had reached the main pod that includes the main cast, directors, assistant directors and director of photography, then it may be a story much like The Batman, which saw its its main star, Robert Pattinson, testing positive.
The production separates itself in a number of groups that do not interact with each other.
Scream 5 is staying on schedule (minus a few days) after three positive cases were found on set due to the production implementing a pod/zone approach that many Hollywood films have adopted, per Deadline.